Literatur Review Vitamin D Terhadap Stres Oksidatif (MDA)

Authors

  • Devi Ardila Universitas Sriwijaya, Indonesia
  • Chessy Sripratiwi Universitas Sriwijaya, Indonesia
  • Dindi Paizer Universitas Sriwijaya, Indonesia
  • Ahmad Nur Siddiq Universitas Sriwijaya, Indonesia
  • Erike Septa Prautami Universitas Sriwijaya, Indonesia
  • Elis Anggeria Universitas Prima Indonesia

DOI:

https://doi.org/10.32524/jksp.v8i2.1507

Keywords:

Vitamin D, Stress Oksidatif dan MDA

Abstract

Vitamin D has many benefits and functions for body metabolism. The prevalence of vitamin D deficiency is still high in Indonesia. Vitamin D deficiency can improve inflammation and oxidative stress, and increase susceptibility to metabolic disorders and infections. Vitamin D deficiency is often associated with increased levels of malondialdehyde (MDA). Malondialdehyde (MDA), the end product of lipid peroxidation, functions as a reliable biomarker to assess the level of oxidative stress in vivo. The purpose of writing this literature review is to analyze the correlation of vitamin D levels with oxidative stress (MDA). Analysis of related literature was obtained from a search in the medical and health journal databases, namely PubMed-MEDLINE and Google Scholar and published in 2010-2025. 8 articles were obtained and included in this literature review. Based on the literature review, the correlation of vitamin D to oxidative stress (MDA) showed its effect. Vitamin D can reduce oxidative stress levels (MDA) in several diseases such as non-alcoholic liver disease, cystic fibrosis (CF), and certain cases such as obesity that can occur in the elderly and children.

References

Asghari, S., Hamedi-Shahraki, S., & Amirkhizi, F. (2021). Vitamin D status and systemic redox biomarkers in adults with obesity. Clinical Nutrition ESPEN, 45. https://doi.org/10.1016/j.clnesp.2021.07.032

Chang, E. (2019). 1,25-Dihydroxyvitamin D decreases tertiary butyl-hydrogen peroxide-induced oxidative stress and increases AMPK/SIRT1 activation in C2C12 muscle cells. Molecules, 24(21). https://doi.org/10.3390/molecules24213903

Eberhardt, M. (2001). Reactive oxygen metabolites (2nd ed.). CRC Press;

Kaur, J., Khare, S., Sizar, O., & Givler, A. (2025). Vitamin D Deficiency. Stat Pearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK532266/

Khoubnasabjafari, M., Ansarin, K., & Jouyban, A. (2015). Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders. BioImpacts, 5(3). https://doi.org/10.15171/bi.2015.20

Kim, D. H., Meza, C. A., Clarke, H., Kim, J. S., & Hickner, R. C. (2020). Vitamin D and endothelial function. In Nutrients (Vol. 12, Issue 2). https://doi.org/10.3390/nu12020575

Kumar, J., Sharma, A., Dasgupta, A., Podder, A., Naregal, G., Iqbal, M. K., Nazim, S., & Rehman, H. (2024). Unraveling the Relationship Between Vitamin D and Oxidative Stress: A Cross-Sectional Study. Cureus. https://doi.org/10.7759/cureus.67818

Lin, A. M. Y., Chen, K. B., & Chao, P. L. (2005). Antioxidative effect of vitamin D3 on zinc-induced oxidative stress in CNS. Annals of the New York Academy of Sciences, 1053. https://doi.org/10.1196/annals.1344.028

Mokhtari, Z., Hekmatdoost, Z., & Nourian, M. (2017). Antioxidant efficacy of vitamin D. In Journal of Parathyroid Disease (Vol. 5, Issue 1).

Mulianto, N. (2020). Malondialdehid sebagai Penanda Stres Oksidatif pada Berbagai Penyakit Kulit. Cermin Dunia Kedokteran, 47(1).

Octavius, G. S., Shakila, A., Meliani, M., & Halim, A. (2023). Vitamin D deficiency is a public health emergency among Indonesian children and adolescents: a systematic review and meta-analysis of prevalence. Annals of Pediatric Endocrinology and Metabolism, 28(1). https://doi.org/10.6065/apem.2244170.085

Pereira-Santos, M., Costa, P. R. F., Assis, A. M. O., Santos, C. A. S. T., & Santos, D. B. (2015). Obesity and vitamin D deficiency: A systematic review and meta-analysis. Obesity Reviews, 16(4). https://doi.org/10.1111/obr.12239

Petersen, K. S., & Smith, C. (2016). Ageing-associated oxidative stress and inflammation are alleviated by products from grapes. In Oxidative Medicine and Cellular Longevity (Vol. 2016). https://doi.org/10.1155/2016/6236309

Queiroz, D. J. M., Silva, A. S., Júnior, C. C. da S., Persuh, D. C., Diniz, A. da S., de Lima, R. L. F. C., de Paiva, M. P., Cartaxo, C. G. B., Bezerra, P. G. de M., Ribeiro, M. D., & Gonçalves, M. da C. R. (2023). Vitamin D levels and their association with oxidative stress and inflammation markers in patients with cystic fibrosis. Nutricion Hospitalaria, 40(2). https://doi.org/10.20960/nh.04253

Rebelos, E., Tentolouris, N., & Jude, E. (2023). The Role of Vitamin D in Health and Disease: A Narrative Review on the Mechanisms Linking Vitamin D with Disease and the Effects of Supplementation. In Drugs (Vol. 83, Issue 8). https://doi.org/10.1007/s40265-023-01875-8

Sepidarkish, M., Farsi, F., Akbari-Fakhrabadi, M., Namazi, N., Almasi-Hashiani, A., Maleki Hagiagha, A., & Heshmati, J. (2019). The effect of vitamin D supplementation on oxidative stress parameters: A systematic review and meta-analysis of clinical trials. In Pharmacological Research (Vol. 139). https://doi.org/10.1016/j.phrs.2018.11.011

Sharifi, N., Amani, R., Hajiani, E., & Cheraghian, B. (2014). Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial. Endocrine, 47(1). https://doi.org/10.1007/s12020-014-0336-5

Sies, H. (2007). Total antioxidant capacity: Appraisal of a concept. In Journal of Nutrition (Vol. 137, Issue 6). https://doi.org/10.1093/jn/137.6.1493

Siti, H. N., Kamisah, Y., & Kamsiah, J. (2015). The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). In Vascular Pharmacology (Vol. 71). https://doi.org/10.1016/j.vph.2015.03.005

Sulaiman, A. G., & Sangging, P. R. A. (2024). Malondialdehyde (MDA)sebagai Marker Stres Oksidatif Berbagai Penyakit. Medula, 14(2), 321–325. https://www.journalofmedula.com/index.php/medula/article/download/990/785/5958

Untari, U., Anjani, G., Fulyani, F., Pramono, A., Mahati, E., Putri, S. R., & Maulana, R. A. (2023). The Effect of Liprotide-Encapsulated Vitamin D3 on MDA and SOD in Rats Deficient Vitamin D and Calcium. Journal of Biomedicine and Translational Research, 9(1). https://doi.org/10.14710/jbtr.v9i1.16289

Webb, A. R., Decosta, B. R., & Holick, M. F. (1989). Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. Journal of Clinical Endocrinology and Metabolism, 68(5). https://doi.org/10.1210/jcem-68-5-882

Wimalawansa, S. J. (2019). Vitamin D deficiency: Effects on oxidative stress, epigenetics, gene regulation, and aging. In Biology (Vol. 8, Issue 2). https://doi.org/10.3390/biology8020030

Wimalawansa, S. J. (2024). Physiology of Vitamin D—Focusing on Disease Prevention. Nutrients, 16(11), 1666. https://doi.org/10.3390/nu16111666

Zahra, N., Johan, A., & Ngestiningsih, D. (2019). Hubungan Antara Kadar Vitamin D Dengan Kadar Malondialdehid (Mda) Plasma Pada Lansia. Diponegoro Medical Journal (Jurnal Kedokteran Diponegoro), 8(1).

Published

2025-06-30

How to Cite

Ardila, D., Sripratiwi, C., Paizer, D., Nur Siddiq, A., Septa Prautami, E., & Anggeria, E. (2025). Literatur Review Vitamin D Terhadap Stres Oksidatif (MDA). Jurnal Kesehatan Saelmakers PERDANA (JKSP), 8(2). https://doi.org/10.32524/jksp.v8i2.1507